Ajax will be looking to increase their chances of progressing from Group H by taking all three points away from their trip to France on Wednesday night.
The Dutch champions are tied with Chelsea and Valencia on seven points, whilst Lille have only one point from their four points.
Ajax were convincing 3-0 winners away to Valencia and led 4-1 at Chelsea before being reduced to nine men. They still managed to hold out for a point.
Lille’s only point came at home to Valencia, and they were only beaten 2-1 by Chelsea at the Stade Pierre Mauroy.
However, Erik ten Hag’s tactics should see Ajax take another three points on the road against the weakest team in the group. They were also 3-0 winners at home to Lille back in September.
Quincy Promes, Donny van de Beek and Hakim Ziyech are all goalscoring threats in open play and on the counter-attack for the visitors midweek.
Although they are odds on favourites I still think there is very good value in backing Ajax as three points will be important to them before hosting Valencia in their final group game.
Best bet: Ajax to win is 1.93 with Betfair